Full Name: George Kokotos gkokotos@atlas.uoa.gr
Title: Professor
Education:
  • B.Sc. in Chemistry, University of Athens (1979)
  • Ph.D. in Chemistry (Organic Chemistry), University of Athens (1984)
  • Research Fellow at the University of London (1990-1991).
Laboratory: Laboratory of Organic Chemistry (Tel: ++30-210-7274462, Tel./Fax: ++30-7249101)
Teaching Undergraduate:
Organic chemistry, Bioorganic Chemistry
Graduate:
Synthesis of Organic Compounds with Biological Activity
Fields of
Interest:
  • Development of new methods for the synthesis of unnatural amino acids and derivatives.
  • Synthesis and study of inhibitors for lipolytic enzymes
  • Synthesis of fluorogenic substrates for the determination and study of proteases.
  • Synthesis of organic compounds exhibiting biological activity (e.g. anti-inflammatory, cytotoxic activity).
  • Biotransformations in organic sysnthesis.
Book
authorship:
  1. "Topics in Bioorganic Chemistry" (Athens, 1993, in Greek, with one co-author)
Publications: More than 45 research publications in international scientific journals of Organic, Biological and Medicinal Chemistry as well as Biochemistry.

Recent Publications

  1. “A GENERAL APPROACH TO THE ENANTIOMERIC SYNTHESIS OF LIPIDIC a -AMINO ACIDS, PEPTIDES AND VICINAL AMINO ALCOHOLS”. G. Kokotos, J.-M. Padron, C. Noula, W.A. Gibbons and V. Martin, Tetrahedron: Asymmetry, 7, 857-866, 1996.

  2. “SYNTHESIS OF LIPIDIC AMINO ACID AND DIPEPTIDE INHIBITORS OF HUMAN PLATELET PHOSPHOLIPASE A2”. G. Kokotos, V. Constantinou, C. Noula, A. Nicolaou and W.A. Gibbons, Int. J. Peptide Protein Res., 48, 160-166, 1996.

  3. “SYNTHESIS OF CHIRAL TRIAMINES AND DIAMINES FROM AMINO ACIDS”. G. Kokotos, T. Markidis and V. Constantinou, Synthesis, 1223-1226, 1996.

  4. “A SELECTIVE ONE POT CONVERSION OF CARBOXYLIC ACIDS INTO ALCOHOLS”. G. Kokotos and C. Noula, J. Org. Chem., 61, 6994-6996, 1996.

  5. “SYNTHESIS OF MEDICINALLY USEFUL LIPIDIC a -AMINO ACIDS, 2-AMINO ALCOHOLS AND DIAMINES”. G. Kokotos, V. Martin, V. Constantinou and W.A. Gibbons, Amino Acids, 11, 329-343, 1996.

  6. “CONVENIENT SYNTHESIS OF BENZYL AND ALLYL ESTERS USING BENZYL AND ALLYL 2,2,2-TRICHLOROACETIMIDATE”. G. Kokotos and A. Chiou, Synthesis, 168-170, 1997.

  7. “NEW FLUOROGENIC SUBSTRATES FOR THE STUDY OF SECONDARY SPECIFICITY OF PROLYL OLIGOPEPTIDASE”. C. Noula, G. Kokotos, T. Barth and C. Tzougraki, J. Peptide Res., 49,46-51, 1997.

  8. “AN HPLC METHOD FOR THE MEASUREMENT OF POLYAMINES AND LIPIDIC AMINES BINDING TO DNA”. G. Karikas, V. Constantinou and G. Kokotos, J. Liq. Chrom. & Rel. Technol., 20, 1789-1796, 1997.

  9. “SYNTHESIS AND PROPERTIES OF NOVEL LIPOPEPTIDES AND LIPID MIMETICS”. A. Nicolaou, G. Kokotos, V. Constantinou, C. Charitos, C. Noula, R. Verger and W.A. Gibbons, J. Peptide Science, 3, 291-298, 1997.

  10. “STOICHIOMETRIC MEASUREMENT OF DNA DAMAGE CAUSED BY 8-METHOXY-PSORALEN AND UVA”. G. Karikas, K. Schulpis, G. Kokotos, T. Michas and S. Georgala, Clin. Biochem., 30, 439-442, 1997.

  11. “SYNTHESIS AND IN VITRO CYTOTOXICITY OF AMINOCOUMARIN PLATINUM(II) COMPLEXES”. G. Kokotos, V. Theodorou, C. Tzougraki, D. Deforce and E. Van den Eeckhout, Bioorg. Med. Chem. Lett., 7, 2165-2168, 1997.

  12. “DIRECT MOLECULAR INTERACTION OF PHENYLALANINE WITH DNA MEASURED BY A REVERSED PHASE HPLC METHOD”. K. Schulpis, G. Karikas and G. Kokotos, Clin. Chem., 44, 178-179, 1998.

  13. “MEASUREMENT OF MOLECULAR INTERACTIONS OF ASPARTAME AND ITS METABOLITES WITH DNA”. G. Karikas, K. Schulpis, G. Reclos and G. Kokotos, Clin. Biochem., 31, 405-407, 1998.

  14. “A GENERAL APPROACH TO THE ASYMMETRIC SYNTHESIS OF UNSATURATED LIPIDIC a -AMINO ACIDS. THE FIRST SYNTHESIS OF a -AMINOARACHIDONIC ACID”. G. Kokotos, J.M. Padron, T. Martin, W.A. Gibbons and V.S. Martin, J. Org. Chem., 63, 3741-3744, 1998.

  15. “SYNTHESIS AND IN VITRO CYTOTOXICITY OF LIPOPHILIC PLATINUM(II) COMPLEXES”. G. Kokotos, V. Theodorou,. V. Constantinou, W.A. Gibbons, C. Roussakis, Bioorg. Med. Chem. Lett., 8, 1525-1530, 1998.

  16. “SYNTHESIS AND IN VITRO CYTOTOXICITY OF LIPIDIC ALCOHOLS AND AMINES”. V. Constantinou, G. Kokotos and C. Roussakis, Anticancer Res., 18, 3439-3442, 1998.

  17. “PREPARATIVE CAPILLARY ZONE ELECTROPHORESIS IN COMBINATION WITH OFF-LINE GRAPHITE FURNACE ATOMIC ABSORPTION FOR THE ANALYSIS OF DNA COMPLEXES FORMED BY A NEW AMINOCOUMARIN PLATINUM(II) COMPOUND”. D.L.D. Deforce, G. Kokotos, E.L. Esmans, A. De Leenheer and E.G. Van den Eeckhout, Electrophoresis, 19, 2454-2458, 1998.

  18. “ENANTIOSPECIFIC SYNTHESIS OF a -AMINO ACIDS SEMIALDEHYDES : A KEY STEP FOR THE SYNTHESIS OF UNNATURAL UNSATURATED AND SATURATED a -AMINO ACIDS”. J.M. Padron, G. Kokotos, T. Martin, T. Markidis, W.A. Gibbons and V.S. Martin, Tetrahedron : Asymmetry, 9, 3381-3394, 1998.

  19. “SYNTHESIS OF OPTICALLY ACTIVE LIPIDIC a -AMINO ACIDS AND LIPIDIC 2-AMINO ALCOHOLS”. V. Constantinou and G. Kokotos, Amino Acids, 1998, in press.

Patents

  1. “2-Amino-alkanoic acid derivatives, 2-amino alcohols and diamines, the processes for their preparation and their uses” V. Martin and G. Kokotos, UK .Patent, 2 323 594 A 1998 ( Appl. 25 Mar 1997).