Full Name: Athanasios Yiotakis
Title: Professor
Director of the Laboratory of Organic Chemistry
Education:
  • B.Sc. in Chemistry, University of Athens (1967)
  • Ph.D. in Chemistry (Organic Chemistry), University of Athens (1973)
  • Post Doctoral studies at the Case Western Reserve University, Cleveland, OHIO (1974-1976).
Laboratory: Laboratory of Organic Chemistry (Tel: ++30-210-7274498, Tel./Fax: ++30-210-7249101)
Teaching Undergraduate:
Organic Chemistry
Graduate:
Advanced Organic Chemistry
Fields of
Interest:
  • Chemistry of amino acids, peptides and pseudopetpides.
  • Synthetic methods for the development of potent and selective metalloproteasephosphorous containing inhibitors.
Book
authorship:		  
Publications: More than 30 research publications in international scientific journals of Organic, Biological and Medicinal Chemistry as well as Biochemistry.

Recent Publications

  1. A. YIOTAKIS, A. LECOQ, S. VASSILIOU, I. RAYNAL, P- CUNIASSE AND V. DIVE: "Cyclic peptides with a Phosphinic Bond as potent inhibitors of a Zinc Bacterial Collagenase". J. Med. Chem., 37, 2713 (1994).
  2. A. YIOTAKIS, A. LECOQ, A. NICOLAOU, J. LABADIE and V. DIVE: "Phosphinic peptide analogues as potent inhibitors of corynebacterium rathayii bacterial collagenase". Biochem. J., 303, 323 (1994).
  3. P. CUNIASSE, I. RAYNAL, A. LECOQ, A. YIOTAKIS and V. DIVE: "Three Dimentional Structure of Cyclohexapeptides containing a Phosphinic Bond in Aqueous Solution: A Template for Zinc Metalloprotease inhibitors. A NMR and Restrained Molecular Dynamics Study". J. Med. Chem., 38, 553 (1995).
  4. B. VINCENT, V. DIVE, A. YIOTAKIS, C. SMADJA, J.-P. VINCENT and F. CHECLER: "Phosphorous containic peptides as mixed inhibitors of endopeptidase 3.4.24.15 and 3.4.24.16: effect on neurotensin degradation in vitro and in vivo". Br. J. Pharmacology, 115, 1053 (1995).
  5. J. JIRACEK, A. YIOTAKIS, B. VINCENT, A LECOQ, A.NICOLAOU, F. CHECLER and V. DIVE: "Development of highly potent and selective phosphinic peptide inhibitors of zinc Endopeptidase 24-15 using combinatorial chemistry". J. Biol. Chem., 270, 21701 (1995).
  6. J. JIRACEK, A. YIOTAKIS, B. VINCENT, F. CHECLER and V. DIVE. "Development of the first potent and selective Inhibitor of the Zinc Endopeptidase Neurolysin using a systematic Approach based on combinatorial chemistry of phosphinic peptides". J. Biol. Chem., 271, 19606 (1996).
  7. F. GRAMS, V. DIVE, A. YIOTAKIS, I. YIALLOUROS, S. VASSILIOU, R. ZWILLING, W. BODE, W. STOCKER: "Structure of Astacin with a transition-state analogue inhibitor" Nature structural biology 3, 671 (1996).
  8. A. YIOTAKIS, S. VASSILIOU, J. JIRACEK and V. DIVE: "Protection of the hydroxyphosphinyl function of phosphinic dipeptides by Adamantyl. Application to the solid-phase synthesis of phosphinic peptides". J. Org. Chem. 61, 6601 (1996).
  9. P. CUNIASSE, I. RAYNAL, A. YIOTAKIS and V. DIVE: "Accounting for conformational variability in NMR structure of cyclopeptides". J. Am.Chem. Soc. (1997).