A Recent Publication from the Laboratory of Organic Chemistry from the group of Associate Professor Christoforos Kokotos appeared in Green Chemistry (impact Factor 10.18) from the Royal Chemical Society

A recent publication from Nikoleta Spiliopoulou (PhD candidate) and Associate Professor Christoforos G. Kokotos entitled: «Photochemical metal-free aerobic oxidation of thiols to disulfides », which was carried out in the Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens appeared in the highly ranked international journal Green Chemistry (Impact factor 10.18).

The methodology (Green Chem., 2021, 23, 546) describes a novel and green organocatalytic photochemical transformation for the synthesis of both symmetrical and non-symmetrical disulfides from thiols. The developed protocol employs a small organic molecule (phenylglyoxylic acid) as the photoinitiator and is carried out under very mild conditions by irradiation employing either household lamps or sunlight. This novel methodology could find application in the synthesis of non-symmetrical disulfides, which very recently were introduced in literature as inhibitors of the SARS-Cov-2019 protein.


Publication Link: https://pubs.rsc.org/en/content/articlelanding/2021/GC/D0GC03818K